Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable:
Manchester City goalkeeper Joe Hart has joined Serie A side Torino on loan until the end of the season, the player's agent confirmed on Tuesday. The 29-year-old has been out of favour at Manchester City since the arrival of new manager Pep Guardiola and dropped to number three in the pecking order behind 17 million pound ($22.23 million) signing Claudio Bravo and Willy Caballero.
IMAGES from League Cup matches played on Wednesday.
It wasn't his players' performance but a luck not going his way -- not once but twice -- that saw the Spaniard lose his cool.
Lampard initially joined City on loan for six months from the New York City Red Bulls after leaving Chelsea at the end of last season.
Manchester United have lost 11 of their 27 league matches this campaign, two more than all of last season. The two previous seasons with 12 league losses (2013-14 and 2021-22) led to managerial changes.
Gundogan was Pep Guardiola's first recruit when he took over the reins at City in 2016 despite the German being sidelined with a knee injury when he was signed from Borussia Dortmund.
Haaland's 45th goal was a personal record, too, for the 22-year-old who scored a total of 44 in 2019-20
Former England midfielder Frank Lampard's decision to stay with Manchester City until the end of the season has "outraged" fans of Major League Soccer team New York City FC.
Breakaway Super League clubs Real Madrid, Manchester City and Chelsea are likely be banned from this season's Champions League semi-finals, UEFA executive committee member Jesper Moller told Danish broadcaster DR on Monday.
Liverpool's first match since being confirmed as champions is at City's stadium and Pep Guardiola said his players would pay tribute to Juergen Klopp's title-winning side.
Manchester City continued their imperious stranglehold over the League Cup with a 2-1 victory over Aston Villa with goals from Sergio Aguero and Rodri in the final at Wembley on Sunday to win the trophy for a third straight season. City became the first side to win the competition three seasons in a row since Liverpool claimed four straight titles from 1981 to 1984.
The new English season got off to a familiar start as two Sergio Aguero goals, including his 200th for the club, handed Manchester City a 2-0 win over Chelsea and claim the FA Community Shield for the fifth time at a sun-baked Wembley.
Leroy Sane struck the winner as Manchester City beat Liverpool 2-1 in a gripping English Premier League clash.
Former England forward Trevor Francis, Britain's first one million pound ($1.28 million) player, has died at the age of 69 after suffering a heart attack, his family said on Monday.
Guardiola said City had plenty of options, with Gabriel Jesus the only main striker fit and ready but Ilkay Gundogan and Raheem Sterling are able to slot into the role.
Lionel Messi, who is Barcelona's all-time top scorer with 634 goals in 731 games, is expected to spend three seasons at Manchester City before moving to CFG's Major League Soccer franchise New York City FC.
Manchester City's bid to chop Arsenal's Premier League lead to two points was scuppered as Harry Kane's record-breaking goal earned Tottenham Hotspur a 1-0 win.
Holders Manchester City began their assault on the FA Cup with a 4-1 victory over fourth-tier Port Vale but Manchester United and Wolverhampton Wanderers face an unwanted replay after drawing 0-0 at Molineux on Saturday. Goals from Oleksandr Zinchenko, Sergio Aguero, Taylor Harwood-Bellis and Phil Foden made it a routine day for City, although Tom Pope had equalised for a Vale side sitting 74 places lower in the standings.
Leaders Manchester City were held to a 0-0 draw at Crystal Palace
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
Ruthless Arsenal threw down the gauntlet in the Premier League title race with a 5-0 thrashing of London rivals Chelsea to roar three points clear at the top of the table on Tuesday.
Xherdan Shaqiri inspired StokeCity to a convincing 2-0 victory over Premier League leaders ManchesterCity in blustery conditions at the Britannia Stadium on Saturday.
The former Borussia Dortmund player was substituted as a precaution early in the second half of the 3-2 defeat at Brighton & Hove Albion in the Premier League on May 18.
A summary of the opening day's action in the UEFA Champions league on Tuesday.
Crystal Palace, who missed a stoppage-time penalty, became only the second team to take points off Manchester City in the English Premier League this season when they held the runaway leaders to a 0-0 draw at Selhurst Park on Sunday.
'We believe in ourselves, we believe we're a top team.'
A round-up of Wednesday's action in the UEFA Champions League
Unsettled striker Carlos Tevez returned to Manchester City on Monday and the English city he had sworn he would never return to.
Images from the English Premier League matches played on Saturday.
LeicesterCity went level on points with Premier League leaders Arsenal after drawing 0-0 with title rivals ManchesterCity at the King Power Stadium on Tuesday.
City having already bagged the title and Newcastle safe, there was nothing riding on the fixture but it served up some rich entertainment
Manchester United surged nine points clear at the top of the Premier League with an edgy 3-1 victory over Manchester City.
Aguero's absence means a likely start for Brazilian Gabriel Jesus in attack.
Australia were taunted ahead of the fourth Ashes Test against England with a giant billboard of Ben Stokes saying 'Welcome to Manchester' outside the team hotel on Wednesday.
IMAGES from the English Premier League matches played on Sunday.
Ahead of the all-important clash, Rediff.com looks at five memorable derbies between the fierce rivals.
Manchester City humbled their neighbours United by beating them 6-1 and Levante still lead in Spain where European champions Barcelona were held to a 0-0 draw by Sevilla.
Arsenal reclaim provisional top spot with 1-0 win at Man United
Liam Delap, the son of former Stoke City defender Rory, scored the opener for Pep Guardiola's side in the 2-1 win at the Etihad Stadium
