Ahead of the all-important clash, Rediff.com looks at five memorable derbies between the fierce rivals.
IMAGES from the EPL matches played on Saturday
It rains hard and often and is a far cry from the beaches of Barcelona, yet Argentina striker Sergio Aguero believes world player of the year Lionel Messi would find Manchester to his liking. Manchester City striker Aguero said he had extolled the virtues of England's north-west city to his compatriot and Barcelona forward who is the most valuable player in the game. Messi, 28, has expressed no desire to leave Barca, where he is contracted to until 2019, but Abu-Dhabi owned Manchester City, backed by the billions of Sheikh Mansour, are one of the few clubs who could afford to buy him. "He already knows there's no beach!," Aguero, who has scored 120 goals in 185 appearances during his four-and-a-half years at the Etihad, told Sky Sports. "We play every three days so we just eat, rest between games -- so the weather is not really that important.
IMAGES from the Premier League matches played on Saturday
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
Louis van Gaal believes the club have become more boring under his successor Jose Mourinho, saying he would prefer to watch local rivals and Premier League leaders Manchester City in action.
The battle for Champions League qualification continues with fourth-placed Aston Villa away to Luton Town on Saturday and Tottenham Hotspur, who are five points behind with a game in hand, hosting Crystal Palace.
Manchester City won the English League Cup for the second successive season as the beat Chelsea 4-3 in a penalty shootout after the Wembley showpiece had ended 0-0 after extra time.
The 30-year-old has said he did not suffer any serious injuries and has returned to training to be available for England's opening Group C match.
City winger Riyad Mahrez and defender Aymeric Laporte previously tested positive for the novel coronavirus earlier this month.
Pep Guardiola is pleased with the Premier League side's improvement and form over the past two months but will not make any premature comparison with his former clubs.
Sachin Tendulkar received a standing ovation from the capacity crowd at Centre Court
The goal was checked by VAR and allowed to stand as Liverpool went on to clinch the victory and move nine points clear of City in the Premier League title race.
The former world number one said she hoped to motivate young girls into sports with the doll.
Manchester City captain Vincent Kompany believes the derby against Manchester United is the biggest fixture of the season and he would feel the same even if the two teams were not involved in the Premier League title race.
IMAGES from the Champions League matches played on Tuesday.
'For the Premier League champions, their appearance in China was nothing more than a commercial obligation, and their lack of enthusiasm and the indifferent treatment of their hosts stands in stark contrast to representatives of other clubs'
Manchester City striker Sergio Aguero has been charged with violent conduct over an incident involving West Ham United defender Winston Reid, the FA said in a statement on Tuesday. The Argentine international now faces a three-match ban that would see him miss Premier League games against Manchester United and Bournemouth and a League Cup third-round tie against Swansea City.
Leandro Trossard transformed the mood at Arsenal with the winning goal as they recovered from an early setback to beat Tottenham Hotspur 2-1 at home.
The 29-year-old missed the last three ManchesterCity games and both of Argentina's World Cup qualifiers earlier this month following his road traffic accident in the Netherlands.
The dynasty will only be built on European success, though, and after the quarter-final exit to Liverpool, Manchester City's owners, who want a gilded continental powerhouse to match United's global lustre, will demand it and back those demands with huge funding.
A summary of Saturday's action in the Premier League.
Lewis Hamilton revealed he is a big Arsenal fan and 'has been waiting for' them to win the Premier League (PL) for his whole life.
Images from the English Premier League matches played on Sunday night.
'I'm probably one of the only ones that disagrees, for the simple fact that we only had three games that we were below standard.'
The abuse occurred after City's Champions League semi-final victory over Paris St Germain on Tuesday.
IMAGES from the English Premier League match played between Everton and Manchester City on Wednesday
For Michael Vaughan, Pep Guardiola is the best sporting leader in the last 15 years and the former England skipper won't mind if Ben Stokes employs Manchester City manager's approach of never allowing players to take their places for granted.
Images from Saturday's action in the Premier League.
Manchester United manager Erik ten Hag will remain in the job for next season and has entered into talks with the Old Trafford club over a contract extension
The paper added that at least four managers as well as players from several teams could be affected.
IMAGES from the English Premier League matches played on Saturday.
Premier League Leeds United suffered the biggest upset of the FA Cup third round when they fell to a 3-0 defeat by fourth-tier Crawley Town on Sunday
Tottenham fell to seventh after winning just one league game in November but have since recovered with a morale-boosting Champions League victory over APOEL Nicosia, followed by two consecutive domestic wins to climb back into the top four.
'It's difficult even for me to find a reason why but you have to insist and talk about the game, the way they play and try to do more, concede as few as possible and score up front.'
Manchester City have never gone past the semi-final stage of Europe's premier club competition.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Gabriel Jesus scored twice, including a 92nd-minute winner, as Manchester City climbed to third in the Premier League with a 2-1 victory against a dogged Swansea City on Sunday.
aka was excellent in the opening minutes and it was his cross that was headed into the net by Martinelli for the opener, but he went down injured shortly afterwards after a challenge from Forest's Renan Lodi. Saka tried to continue but came off after 27 minutes.
Former Chelsea midfielder Frank Lampard began his loan spell at Premier League champions Manchester City on Wednesday, just two weeks after joining Major League Soccer club New York City FC.
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